发明名称 |
MATRIX FOR SEPARATION OF POLYETHERS AND METHOD OF SEPARATION |
摘要 |
<p>The present invention relates to a separation matrix comprised of a support to the surfaces of which polymer chains have been coupled, wherein each polymer chain presents recurring proton-donating groups and at least the surface of the support is substantially hydrophilic. In the most advantageous embodiment, the support is porous cross-linked agarose, the polymers are poly(acrylic acid) and the proton-donating groups are carboxyl groups. The matrix is useful e.g. to remove PEG from pegylated and/or native compounds in a liquid. Accordingly, the invention also encompasses a method, such as a chromatographic method, wherein the separation matrix according to the invention is used, for example as a pre-treatment of a reaction mixture that comprises unreacted PEG, pegylated proteins and native proteins.</p> |
申请公布号 |
WO2005029065(A1) |
申请公布日期 |
2005.03.31 |
申请号 |
WO2004SE01273 |
申请日期 |
2004.09.06 |
申请人 |
AMERSHAM BIOSCIENCES AB;VAN ALSTINE, JAMES;BERGSTROEM, JAN;IHRE, HENRIK;SOEDERMAN, TOBIAS |
发明人 |
VAN ALSTINE, JAMES;BERGSTROEM, JAN;IHRE, HENRIK;SOEDERMAN, TOBIAS |
分类号 |
B01D;B01D15/04;B01D15/32;B01D15/36;B01D15/38;B01J20/286;B01J20/32;(IPC1-7):G01N30/48 |
主分类号 |
B01D |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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