FUSION PROTEINS OF INTERFERON ALPHA MUTEINS WITH IMPROVED PROPERTIES
摘要
The invention concerns human interferon alpha and in particular modified forms of interferon alpha 2 with improved properties. The improved proteins contain amino acid substitutions at specific positions that confer increased relative activity in biological assays. The invention provides also modified interferon alpha with improved biological activity concomitant with reduced immunogenic potential in the protein. The improved proteins are intended for therapeutic use in the treatment of diseases in humans.
申请公布号
WO2004074486(A3)
申请公布日期
2005.03.31
申请号
WO2004EP01524
申请日期
2004.02.18
申请人
MERCK PATENT GMBH;JONES, TIM;BAKER, MATTHEW;HANLON, MARIAN;CARR, FRANCIS, JOSEPH
发明人
JONES, TIM;BAKER, MATTHEW;HANLON, MARIAN;CARR, FRANCIS, JOSEPH