COMPOUNDS THAT MODULATE THE ACTIVITY OF PTP-1B AND TC-PTP
摘要
The present invention relates to a new and improved method for treating diabetes and or its associated complications by modulating the activity of protein tryosin phosphatase 1B ("PTP-1B"). The inventive compounds modulate the activity PTP-1B by binding to a novel binding site referred herein as the PTP-1B exosite that is distal to the active site of PTP-1B. The present invention also relates to a new and improved method of treating immune system disorders by modulating the activity of T-cell protein tyrosine phosphatase ("TC-PTP"). The inventive compound modulate the activity of TC-PTP by binding to a novel binding site referred herein as the TC-PTP exosite that is distal to the active site of PTP-1B.
申请公布号
WO03073987(A3)
申请公布日期
2005.03.31
申请号
WO2003US05950
申请日期
2003.02.26
申请人
SUNESIS PHARMACEUTICALS, INC.;BARR, KENNETH;FAHR, BRUCE;HANSEN, STIG;WIESMANN, CHRISTIAN
发明人
BARR, KENNETH;FAHR, BRUCE;HANSEN, STIG;WIESMANN, CHRISTIAN