发明名称 |
REGULATION OF CARDIAC CONTRACTILITY AND HEART FAILURE PROPENSITY |
摘要 |
The methods and compositions of the present invention find use in altering expression of PKC.alpha. in transgenic animals. The compositions of the invention include isolated transgenic animal cells, transgenic tissue, transgenic animals, and transgenic mice. The transgenic animals of the invention exhibit altered PKC.alpha. activity. The methods allow generation of transgenic animals with altered expression of PKC.alpha.. The invention allo ws modulation of cardiac contractility. In particular, the invention provides a method for altering the susceptibility of a transgenic animal to cardiomyopathy. A transgenic animal of the invention finds use in identifyin g anti-cardiomyopathic compounds.
|
申请公布号 |
CA2538999(A1) |
申请公布日期 |
2005.03.31 |
申请号 |
CA20042538999 |
申请日期 |
2004.09.17 |
申请人 |
UNIVERSITY OF CINCINNATI;CHILDREN'S HOSPITAL MEDICAL CENTER |
发明人 |
MOLKENTIN, JEFFERY DANIEL;KRANIAS, EVANGELIA GALANI |
分类号 |
A01K67/027;A61K38/00;C07K14/47;C12N9/12;C12N15/85 |
主分类号 |
A01K67/027 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|