| 摘要 |
<p>1,188,158. N-Acylated halogeno benzene-2,4- disulphonamides. FARBWERKE HOECHST A.G. 11 July, 1967 [13 July, 1966], No. 31773/67. Heading C2C. Novel compounds I wherein X is a chlorine or bromine atom, R is alkyl, alkoxyalkyl or tetrahydrofurfuryl and R 1 is an alkyl, cycloalkyl or cycloalkyl-alkyl radical which may be substituted by one or more halogen atoms or be singly unsaturated and which may contain up to 8 carbon atoms, or represents a phenyl, furyl, thienyl, phenylalkyl, furylalkyl or thienylalkyl radical which may be substituted in the phenyl radical by one or more substituents selected from halogen atoms and alkyl and alkoxy radicals and in which the alkylene bridge of the phenylalkyl, furylalkyl or thienylalkyl radical may be branched and/or singly unsaturated, are prepared by reacting a sulphohalide II with a reactive derivative of a carboxylic acid, R 1 -COOH, and treating the intermediate sulphohalide with ammonia. Pharmaceutical preparations possessing diuretic and saluretic action contain as active ingredient compounds I and are preferably administered orally.</p> |
