HIGH THROUGHPUT METHOD TO IDENTIFY LIGANDS FOR CELL ATTACHMENT
摘要
<p>A high througtput method is provided for identifying agents capable of producing a desired biological response in whole cells. The method includes the steps of providing receptacles having a culture surface; placing different mixtures of single agents into selective ones of the receptacles according to a statistical design; and immobilizing the mixtures of single agents to the culture surface. The method further includes contacting the immobilized agents with the whole cells; and acquiring data which is indicative of a desired biological response in the contacted cells. The method also includes using statistical modeling of the acquired data to determine which mixtures of single agents and/or which single agents in these mixtures are affective in producing the desired biological response in the contacted cells.</p>
申请公布号
WO2005029071(A1)
申请公布日期
2005.03.31
申请号
WO2004US29578
申请日期
2004.09.10
申请人
BECTON, DICKINSON AND COMPANY;LIEBMANN-VINSON, ANDREA;ROWLEY, JONATHAN, A.;BODILY, CHRIS, H.;HEIDARAN, MOHAMMAD, A.
发明人
LIEBMANN-VINSON, ANDREA;ROWLEY, JONATHAN, A.;BODILY, CHRIS, H.;HEIDARAN, MOHAMMAD, A.