发明名称 |
2-methylene-19-nor-vitamin D2 compounds |
摘要 |
2-Methylene-19-nor-24(S) and 24(R) derivatives of 1alpha,25-dihydroxyvitamin D2 are disclosed. These compounds are characterized by minimal bone calcium mobilization activity and relatively high intestinal calcium transport activity. This results in novel therapeutic agents for the treatment of diseases such as renal osteodystrophy, autoimmune diseases, and osteoporosis. These compounds also exhibit pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as anticancer agents and for use treating skin diseases such as psoriasis.
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申请公布号 |
US2005070511(A1) |
申请公布日期 |
2005.03.31 |
申请号 |
US20040922114 |
申请日期 |
2004.08.18 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
DELUCA HECTOR F.;SICINSKI RAFAL R.;GOWLUGARI SUMITHRA |
分类号 |
A61K31/59;C07C401/00;(IPC1-7):A61K31/59 |
主分类号 |
A61K31/59 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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