发明名称 |
Multiphoton photoacoustic spectroscopy system and method |
摘要 |
A system and method for performing multispectral imaging locates features of interest in a specimen using a technique known as multiphoton photoacoustic spectroscopy. In this technique, a tunable high-power laser is used to initiate multiphoton excitation events which are then detected as an acoustic signal using a sensor such as an ultrasonic piezoelectric transducer. The transducer signal is processed to form a normalized MPPAS signal intensity which may then be used as a basis for forming a spectral image. Unlike other spectroscopies, MPPAS is able to monitor non-fluorescent species based on non-radiative relaxation of the light-absorbing species in the specimen. In addition, since the majority of energy imparted to the light-absorbing molecules is released through non-radiative pathways, sensitive measurements of even fluorescent molecules can be performed. The system and method may be applied to detect malignant cells in tissue samples although other uses are contemplated.
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申请公布号 |
US2005070803(A1) |
申请公布日期 |
2005.03.31 |
申请号 |
US20030721824 |
申请日期 |
2003.11.26 |
申请人 |
CULLUM BRIAN M.;CHANDRASEKHARAN NIRMALA;MEHTA RONAK;SAHA SOUMI |
发明人 |
CULLUM BRIAN M.;CHANDRASEKHARAN NIRMALA;MEHTA RONAK;SAHA SOUMI |
分类号 |
A61B5/00;(IPC1-7):A61B6/00 |
主分类号 |
A61B5/00 |
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