ORTHOPAEDIC DEVICES

摘要

An orthopaedic implant device, for instance a replacement bone implant, has bone-contacting surfaces formed of osteointegration improving materials which have pendant highly hydrophilic groups, and an overall charge at physiological pH. The highly hydrophilic groups are generally zwitterionic groups, for instance phosphory1choline groups. The surface may be formed by coating a device substrate with a polymer comprising zwitterionic groups and ionic groups, and stabilising this on the surface for instance by crosslinking. Human osteoblasts are shown to adhere to the surfaces.