发明名称 Crystals of taxane derivative and process for their production
摘要 A crystal of (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-acetoxy-2-benzoyloxy-9,10-[(1S)-2-(dimethylamino)ethylidenedioxy]-5,20-epoxy-1-hydroxytax-11-en-13-yl (2R,3S)-3-(tert-butoxycarbonylamino)-3-(3-fluoro-2-pyridyl)-2-hydroxypropionate, which has characteristic peaks at diffraction angles (2theta) of 6.2°, 10.3°, 10.7°, 11.4°, and 12.0° in a powder X-ray diffraction pattern, and a method for preparing the aforementioned crystal, which comprises the step of performing crystallization by using an organic solvent selected from the group consisting of a ketone type solvent, a nitrile type solvent, and a mixture thereof, or a mixture of said organic solvent and water.
申请公布号 US2005070579(A1) 申请公布日期 2005.03.31
申请号 US20040495437 申请日期 2004.10.26
申请人 UCHIDA SEISHIRO;TAKAYANAGI YOSHIHIRO;ONO MAKOTO 发明人 UCHIDA SEISHIRO;TAKAYANAGI YOSHIHIRO;ONO MAKOTO
分类号 A61K31/443;A61P35/00;C07D493/04;(IPC1-7):C07D43/02 主分类号 A61K31/443
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