发明名称 |
METHOD OF GENERATING ISLET BETA-CELLS FROM EXOCRINE PANCREATIC CELLS |
摘要 |
The present invention discloses an in vitro method wherein mammalian beta-cell differentiation can be induced in dedifferentiated exocrine pancreatic cells in a medium comprising ligands of the EGF receptor and the GP130 receptor, such as EGF and LIF. Insulin secreting cells, obtainable by this method, provide a means for the treatment of diabetes by islet transplantation. |
申请公布号 |
WO2004113512(A3) |
申请公布日期 |
2005.03.31 |
申请号 |
WO2004BE00089 |
申请日期 |
2004.06.21 |
申请人 |
VRIJE UNIVERSITEIT BRUSSEL;BOUWENS, LUC;BAEYENS, LUC |
发明人 |
BOUWENS, LUC;BAEYENS, LUC |
分类号 |
A61K35/12;C12N5/071 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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