发明名称 |
METHODS AND COMPOSITIONS FOR INHIBITING STAT SIGNALING PATHWAYS |
摘要 |
The invention relates to compositions and methods for modulating cell signaling mediated by signal transducers and activators of transcription (STAT). The compositions target cellular STAT3 and STAT1 protein, particularly STAT3, for degradation via the ubiquitination pathway. Thus, the STAT inhibiting agents are useful for inhibiting STAT mediated signal transduction events, such as responses to IL6 and v-Src, any may be applied to treating diseases associated with activated STAT proteins, particularly STAT3 activity, such as cell proliferative disorders, inflammatory reactions, and autoimmune conditions. |
申请公布号 |
WO2004094605(A3) |
申请公布日期 |
2005.03.31 |
申请号 |
WO2004US12066 |
申请日期 |
2004.04.19 |
申请人 |
MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY;HORVATH, CURT;RODRIGUEZ, JASON;ULANE, CHRSTINE;PARISIEN, JEAN-PATRICK |
发明人 |
HORVATH, CURT;RODRIGUEZ, JASON;ULANE, CHRSTINE;PARISIEN, JEAN-PATRICK |
分类号 |
A61K38/00;A61K48/00;C12N |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|