发明名称 SOLUBLE TGF-beta TYPE III RECEPTOR FUSION PROTEINS
摘要 Soluble fusion proteins of the TGF-ß type III receptor and novel methods for their production are disclosed herein for the first time. The fusion proteins of the invention competitively inhibit the binding of members of the TGF-ß superfamily to their cell-surface receptors. Also provided are methods for using these fusion proteins to modulate the biological activity of members of the TGF-ß superfamily under in vitro or in vivo conditions, and to prevent or treat a variety of pathophysiological conditions associated with overproduction of TGF-ß or mediated by altered signaling pathways of the inhibin/activin system.
申请公布号 WO2005028517(A2) 申请公布日期 2005.03.31
申请号 WO2004US14175 申请日期 2004.05.07
申请人 THE GENERAL HOSPITAL CORPORATION;LIN, HERBERT, Y.;DEL RE, ELISABETTA;SCHNEYER, ALAN, L.;CROWLEY, WILLIAM, F.;BABITT, JODIE, L. 发明人 LIN, HERBERT, Y.;DEL RE, ELISABETTA;SCHNEYER, ALAN, L.;CROWLEY, WILLIAM, F.;BABITT, JODIE, L.
分类号 A61K38/00;C07K14/71 主分类号 A61K38/00
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