发明名称 |
Selective s1p1/edg1 receptor agonists |
摘要 |
The present invention encompasses a method of treating an immunoregulatory abnormality in a mammalian patient in need of such treatment comprising administering to said patient a compound which is an agonist of the S1P1/Edg1 receptor in an amount effective for treating said immunoregulatory abnormality, wherein said compound possesses a selectivity for the S1P1/Edg1 receptor over the S1PR3/Edg3 receptor, said compound administered in an amount effective for treating said immunoregulatory abnormality. Pharmaceutical compositions are included. The invention also encompasses a method of identifying candidate compounds that are agonists of the S1P1/Edg1 receptor and which possesses a selectivity for the S1P1/Edg1 receptor over the S1PR3/Edg3 receptor. The invention further encompasses a method of treating a respiratory disease or condition in a mammalian patient in need of such treatment comprising administering to said patient a compound which is an agonist of the S1P1/Edg1 receptor in an amount effective for treating said respiratory disease or condition, wherein said compound possesses a selectivity for the S1P1/Edg1 receptor over the S1PR3/Edg3 receptor.
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申请公布号 |
US2005070506(A1) |
申请公布日期 |
2005.03.31 |
申请号 |
US20040501176 |
申请日期 |
2004.07.12 |
申请人 |
DOHERTY GEORGE A.;FORREST MICHAEL J.;HAJDU RICHARD;HALE JEFFREY J.;ZHEN LI;MANDALA SUSANNE M.;MILLS SANDER G.;ROSEN HUGH;SCOLNICK EDWARD M. |
发明人 |
DOHERTY GEORGE A.;FORREST MICHAEL J.;HAJDU RICHARD;HALE JEFFREY J.;ZHEN LI;MANDALA SUSANNE M.;MILLS SANDER G.;ROSEN HUGH;SCOLNICK EDWARD M. |
分类号 |
A61K31/00;A61K31/66;G01N33/566;(IPC1-7):A61K31/66 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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