SELF-EMULSIFYING FORMULATIONS OF C HOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS

摘要

CETP inhibitors have improved solubility and bioavailability in a lipophilic vehicle comprising digestible oil, a lipophilic solvent, or a surfactant. Preferred such compositions are self-emulsifyingor self-microemulsifying, and comprise 1. a CETP inhibitor; 2. a cosolvent; 3.a surfactant having an HLB of 1 to 8; 4. a surfactant having an HLB of over 8 to 20; and 5. optionally. a digestible oil.