发明名称 |
Methods of controlling proliferation of cancer cells and cell death |
摘要 |
This invention demonstrates that the PEG10 protein suppresses apoptosis and promotes cancer cell growth. Furthermore, PEG10 protein was found to be degraded through interaction with SIAH1 protein. This invention provides methods of regulating cell growth and cell death using the PEG10 protein. Furthermore, the present invention provides methods of screening for novel anticancer agents which use the PEG10 protein. The screening of this invention enables development of pharmaceutical agents that induce apoptosis and suppress cell growth by specifically targeting cancer cells. In particular, since the PEG10 protein is specifically expressed in hepatoma cells, it is an ideal target molecule for diagnosis and treatment of hepatoma.
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申请公布号 |
US2005070015(A1) |
申请公布日期 |
2005.03.31 |
申请号 |
US20040490581 |
申请日期 |
2004.11.01 |
申请人 |
JAPAN AS REPRESENTED BY THE PRESIDENT OF THE UNIVERSITY OF TOKYO;ONCOTHERAPY SCIENCE, INC. |
发明人 |
NAKAMURA YUSUKE;FURUKAWA YOICHI |
分类号 |
A61K31/7088;A61K38/17;A61K45/00;A61K48/00;A61P35/00;A61P43/00;C12N5/10;C12N15/09;C12Q1/68;G01N33/15;G01N33/50;G01N33/53;G01N33/566;G01N33/574;(IPC1-7):C12Q1/68;C12N15/85 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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