CRIPTO ANTAGONISM OF ACTIVIN AND TGF-beta SIGNALING
摘要
Cripto, a developmental oncoprotein, antagonizes activin and TGF-b signaling by forming a complex with activin and TGF-b and their type II receptors. This complex precludes the formation of a functional activin/TGF-b-type II-type I complex, thereby blocking the signaling of activin and TGF-b. Cripto may be generally capable of blocking antiproliferative Smad2/3 signals and provides a novel mechanism of oncogenic action with multiple therapeutic implications. Inhibiting the formation of Cripto and activin/TGF-b complex may enhance antiproliferative effects of activin and TGF-b.
申请公布号
WO2005028433(A2)
申请公布日期
2005.03.31
申请号
WO2004US29967
申请日期
2004.09.14
申请人
RESEARCH DEVELOPMENT FOUNDATION;VALE, WYLIE;GRAY, PETER, C.;HARRISON, CRAIG, ADAM