SUBSTITUTED INDOLIZINE 1,2,3,6,7,8 DERIVATIVES, FGFS INHIBITORS, A METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES

摘要

The invention relates to derivatives of formula (I), wherein R on the positions 6, 7 or 8 is a hydrogen or halogen atom, a methyl, hydroxy, alkoxy, carboxy, alkoxycarbonyl radical or a radical of formula: -NR5R6, -NH-SO2-Alk, -NH-CO-Alk, -NH-CO2-Alk, -O-Alk-COOR7, -O-Alk-NR5R6, -O-(CH2)n-Ph or -CO-NR5R6; R1 is an alkoxy, carboxy, alkoxycarbonyl radical, a substituted phenyl radical, a heteroaryl radical of 5 or 6 links having one or two optionally substituted heteroatoms; R2 is an alkyl, cycloalkyl radical or an optionally substituted phenyl radical; identical or different R3 and R4 is each a hydroxy, alkoxy, amino, carboxy, alkoxycarbonyl, nitro radical, or a radical of formula: -NR5R6, -NH-CO-Alk, -NH-CO-CF3, -CO- NR5R6 or -CO- NHOH eventually in the form of one of the pharmaceutically acceptable salts thereof.