AZA-QUINOLINOL PHOSPHONATE INTEGRASE INHIBITOR COMPOUNDS

摘要

Aza-quinolinol phosphonate compounds and methods for inhibition of HIV-integrase are disclosed. Formula (I). Ar is aryl or heteroaryl connecting R<6> to L. L is a bond or a linker connecting a ring atom of Ar to N. The ring atoms, X<1>-X<5> may be N, substituted nitrogen, or substituted carbon, and form rings. The compounds include at least one phosphonate group covalently attached at any site.