发明名称 |
N-acetylcysteine compositions and methods for the treatment and prevention of cysteine/glutathione deficiency in diseases and conditions |
摘要 |
Life-threatening hepatotoxicity in the setting of acetaminophen overdose is due to depletion of glutathione (GSH), a vital cysteine-containing tripeptide that protects cells and organs against oxidant injury. Rapid administration of N-acetylcysteine (NAC), which provides the cysteine necessary to replenish the depleted GSH, is the standard of care for preventing injury in acetaminophen overdose. Beneficial effects of NAC treatment have also been demonstrated in respiratory, cardiovascular, endocrine and infectious and other diseases. In fact, over fifty randomized placebo-controlled trials conducted in diverse clinical settings document positive responses to NAC treatment. The present invention relates to cysteine/glutathione (GSH) deficiency as a previously unrecognized clinical entity that can complicate the course of commonly encountered diseases and methods of treatment of this generalized deficiency involving administering N-acetylcysteine (NAC) or a pharmaceutically acceptable salt or derivative to a subject in need thereof and monitoring the subjects appropriate glutathione blood levels as needed.
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申请公布号 |
US2005070607(A1) |
申请公布日期 |
2005.03.31 |
申请号 |
US20040921679 |
申请日期 |
2004.08.19 |
申请人 |
ANDRUS JAMES;HERZENBERG LEONARD;HERZENBERG LEONORE;AIELLO DAVID;MANTOVANI JOHN J. |
发明人 |
ANDRUS JAMES;HERZENBERG LEONARD;HERZENBERG LEONORE;AIELLO DAVID;MANTOVANI JOHN J. |
分类号 |
A61K31/198;C12N;G01N33/48;(IPC1-7):A61K31/198 |
主分类号 |
A61K31/198 |
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