<p>Radiopharmaceutical compounds are disclosed. A tropane compound is linked through the N atom at the 8-position to a chelating ligand capable of complexing technetium or rhenium to produce a neutral labeled complex that selectively binds to the dopamine transporter over the serotonin transporter with a ratio of 10 or more. These compounds can be prepared as separate diastereoisomers as well as a mixture of diastereoisomers. Also disclosed are radiopharmaceutical kits for preparing the labeled radiopharmaceutical compounds. <IMAGE></p>
申请公布号
EP1518561(A2)
申请公布日期
2005.03.30
申请号
EP20040026679
申请日期
1999.10.21
申请人
PRESIDENT AND FELLOWS OF HARVARD COLLEGE;ORGANIX, INC.;THE GENERAL HOSPITAL CORPORATION
发明人
MELTZER, PETER C.;BLUNDELL, PAUL;MADRAS, BERTHA K.;FISCHMAN, ALAN J.;JONES, ALUN G.;MAHMMOD, ASHFAQ