| 摘要 |
The novel heterocyclic derivative of the present invention is a novel heterocyclic derivative having the formula (I')wherein R<1 >is a hydrogen atom or C1-6 alkyl, R<2 >is -CO-C(R<4>)=C(R<4>)-R<5 >wherein R<4 >is a hydrogen atom or C1-4 alkyl, and R<5 >is C4-8 alkyl, C2-8 alkenyl, aryl or aromatic heterocycle, -CO-C=C-R<6 >wherein R<6 >is C1-8 alkyl and the like, R<3 >is a hydrogen atom or C1-4 alkyl, X is an oxygen atom or a sulfur atom, R<20 >is optionally substituted phenyl, and n is an integer of 1 to 4, or a pharmaceutically acceptable salt thereof. The compound (I') of the present invention is useful as a hypoglycemic agent, a hypolipidemic agent, an insulin resistance improver, a therapeutic agent of diabetes, a therapeutic agent of diabetic complications, a glucose tolerance improver, an anti-arteriosclerosis agent, an anti-obesity agent, an antiinflammatory agent, an agent for the prophylaxis or treatment of PPAR-mediated diseases and an agent for the prophylaxis or treatment of syndrome X.
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