| 摘要 |
FIELD: production of biologically active compounds useful in producing of biologically active food supplements, functional foodstuffs, feed additives for prophylaxis of selenium failure in human and animals. ^ SUBSTANCE: bioactive substance selenopyran has antioxidant, antiatherogenic, detoxifying, hypolipidemic, immunomodulating and other properties, as well as anabolic effect. Method for production thereof includes providing of 9-phenyl-symmetric octahydroxanthene slurry in ice acetic acid. Then slurry is saturated in inert atmosphere with hydrogen chloride for 15 min and further with mixture of hydrogen selenide and hydrogen chloride for 15 min. Then hydrogen selenide is passed for 2 hours. Preferable temperature of aqueous solution is 20-50°C, and total hydrogen selenide consumption is 2.3-2.3 l. After dissolving of 9-phenyl-symmetric octahydroxanthene acetic anhydride is introduced into reaction mixture and saturation with hydrogen selenide is carried out. Precipitated crystal deposit is filtered and recrystallized from acetone with filtration of hot solution through filter to produce selenopyran with yield up to 92-96 %; purity of at least 92.2 % and selenium content in target product of 23.2-24.0 %. ^ EFFECT: effective and accelerated method for bioactive selenopyran production with increased yield. ^ 13 cl, 5 tbl, 11 ex |
