发明名称 |
N-ФЕНИЛАРИЛСУЛЬФОНАМИД, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ УКЗАННОЕ СОЕДИНЕНИЕ В КАЧЕСТВЕ АКТИВНОГО ИНГРИДИЕНТА, СОЕДИНЕНИЕ, ЯВЛЯЮЩЕЕСЯ ПРОМЕЖУТОЧНЫМ В СИНТЕЗЕ УКАЗАННОГО СОЕДИНЕНИЯ, И СПОСОБ ЕГО ПОЛУЧЕНИЯ |
摘要 |
<CHEM> (R<1> is COOH etc.; R<2> is hydrogen, methyl, etc.; R<3> and R<4> are a combination of methyl and methyl, etc.; R<5> is isopropyl etc.; Ar is thiazolyl, pyridyl, 5-methyl-2-furyl each optionally substituted with methyl; n is zero or 1), a synthetic intermediate for the compound and a process for its preparation. The compound of formula (I) binds to a prostaglandin E2 receptor, especially an EP1 subtype receptor, and antagonizes it. It is less affected by protein binding, so it has a satisfactory in vivo activity. Therefore, it is considered to be useful as an analgesic, an antipyretic agent, an agent for the treatment of pollakiuria (frequent urination) and/or lower urinary tract disease syndrome or an antineoplastic agent. |
申请公布号 |
RU2003127677(A) |
申请公布日期 |
2005.03.27 |
申请号 |
RU20030127677 |
申请日期 |
2002.03.11 |
申请人 |
ОНО ФАРМАСЬЮТИКАЛ КО., ЛТД. (JP) |
发明人 |
НАГАНАВА Ацуси (JP);САИТОХ Тецудзи (JP);КОБАЯСИ Каору (JP);МАРУЯМА Такаюки (JP);НАКАИ Ёсихико (JP);ХАСИМОТО Синсуке (JP) |
分类号 |
C07D307/64;A61K31/34;A61K31/341;A61K31/41;A61K31/4245;A61K31/426;A61K31/427;A61K31/4402;A61K31/4406;A61K31/4439;A61P1/04;A61P13/00;A61P13/02;A61P29/00;A61P35/00;A61P43/00;C07D213/70;C07D213/71;C07D277/20;C07D277/36;C07D401/12;C07D405/12;C07D413/12;C07D417/12 |
主分类号 |
C07D307/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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