Apparatus for the separation and/or analysis of target molecules in a complex mixture, e.g. DNA or RNA or proteins, has a matrix of micro-columns each with an immobilized probe for a specific bonding with a target molecule

摘要

The apparatus for the detection and/or separation of a number of molecular targets, in a solution of a complex mixture, has a matrix (2) of micro-columns each with an immobilized molecular probe for a specific bonding with a target molecule. An upper (3) network of capillaries delivers the complex mixture to the micro-columns by a plunger (6) from a lateral channel (31). The apparatus for the detection and/or separation of a number of molecular targets, in a solution of a complex mixture, has a matrix (2) of micro-columns each with an immobilized molecular probe for a specific bonding with a target molecule. An upper (3) network of capillaries delivers the complex mixture to the micro-columns by a plunger (6) from a lateral channel (31). A second capillary network (4), linked to a secondary lateral channel (7), carries the target molecules after elution through a channel (41) towards one or more detectors (5) e.g. a mass spectrometer, for recovery and/or analysis.