MODIFIED GENE-SILENCING NUCLEIC ACID MOLECULES AND USES THEREOF

摘要

Methods and means for efficienty downregulating the expression of a target gene of interest in cell from an organism that is an animal, fungus and protist. The invention provides chimeric nucleic acid molecules for down regulating target genes. The invention also provides modified cells and organisms comprising the chimeric nucleic acid molecules and compositions comprising the chimeric molecules.