| 摘要 |
FHOD2 has been identified as a type 2 diabetes susceptibility gene. Methods for diagnosing and treating type 2 diabetes and methods for identifying compounds for use in the diagnosis and treatment of diabetes are disclosed. Improved diagnostic methods for early detection of a risk for developing type 2 diabetes mellitus in humans, and screening assays for therapeutic agents useful in the treatment of type 2 diabetes mellitus, by analyzing the FHOD2 gene or gene products from FHOD2, including variants forms of FHOD2, are disclosed. Indicators of diabetes include variant forms of the FHOD2 protein, variant forms of FHOD2 pre-mRNA or mRNA or variant forms of the genomic DNA of the FHOD2 gene or DNA surrounding FHOD2.
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