| 摘要 |
De novo organogenesis of a joint or portion thereof by osteochondral constructs comprising adult mesenchymal stem cells (MSCs) encapsulated on a scaffold is disclosed. MSCs-derived chondrogenic and osteogenic cells can be loaded in hydrogel monomer suspensions in distinct stratified and yet integrated layers that are sequentially photopolymerized in a mold. Constructs can be then implanted in vivo in a host and fabricated therein or, alternatively, the constructs can be incubated ex vivo, both procedures producing a functional joint or portion thereof. |
