发明名称 |
PROTEASOME PATHWAY INHIBITORS AND RELATED METHODS |
摘要 |
The disclosure provides compositions and methods for blocking the proteasome pathway, as well as compounds that block mitotic cell cycle progression. Compounds disclosed include a family of molecules that bind to a multiubiquitin chain attached to a protein and thereby inhibit degradation of that protein by the proteasome pathway. According to another aspect of the disclosure, compounds are provided that inhibit cell cycle progression. Compounds disclosed herein may be formulated for pharmaceutical use and employed in methods for treating cancers or other hyperproliferative disorders. |
申请公布号 |
WO2005025515(A2) |
申请公布日期 |
2005.03.24 |
申请号 |
WO2004US29909 |
申请日期 |
2004.09.13 |
申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY;DESHAIES, RAYMOND;KING, RANDALL;VERMA, RATI |
发明人 |
DESHAIES, RAYMOND;KING, RANDALL;VERMA, RATI |
分类号 |
A61K;A61K31/195;A61K31/277;A61K31/40;A61K31/44;A61K31/655;A61K31/695;A61K31/785;A61K31/795 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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