发明名称 |
Methods to increase plasma HDL cholesterol levels and improve HDL functionality with probucol monoesters |
摘要 |
It has been discovered that certain selected probucol monoesters, and their pharmaceutically acceptable salts or prodrugs, are useful for increasing circulating HDL cholesterol. These compounds may also improve HDL functionality by (a) increasing clearance of cholesteryl esters, (b) increasing HDL-particle affinity for hepatic cell surface receptors or (c) increasing the half life of apoAI-HDL.
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申请公布号 |
US2005065121(A1) |
申请公布日期 |
2005.03.24 |
申请号 |
US20040977752 |
申请日期 |
2004.10.29 |
申请人 |
SIKORSKI JAMES A.;SAXENA UDAY;LUCHOOMUN JAYRAZ;SUNDELL CYNTHIA L. |
发明人 |
SIKORSKI JAMES A.;SAXENA UDAY;LUCHOOMUN JAYRAZ;SUNDELL CYNTHIA L. |
分类号 |
A61K45/00;A61K31/05;A61K31/10;A61K31/138;A61K31/198;A61K31/216;A61K31/22;A61K31/225;A61K31/235;A61K31/255;A61K31/275;A61K31/40;A61K31/4184;A61K31/4422;A61K31/4706;A61K31/472;A61K31/502;A61K31/506;A61K31/517;A61K31/55;A61K31/554;A61K31/575;A61K45/06;A61P3/06;A61P9/10;C07C323/20;C07C323/21;(IPC1-7):A61K31/66;A61K31/397;A61K31/445;A61K31/401 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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