PROCESS FOR PREPARING WATER SOLUBLE DITERPENES AND THEIR APPLICATIONS

摘要

Aqueous solutions of diterpenes such as Forskolin, its congeners, analogs an d derivatives, up to approximately 6% concentration, are prepared using suitab ly substituted cyclodextrin as a solubilizing agents. In the absence of cyclodextrin, some diterpenes such as Forskolin are soluble in water only to concentrations of about 0.001 % .Such aqueous solutions find applications in topical and systemic use, as pharmaceutical, cosmeceutical, nutraceutical preparations containing diterpenes such as Forskolin and congeners.