Total synthesis of galanthamine, analogues and derivatives thereof

摘要

The invention relates to a method for the synthesis of galanthamine, the derivatives and analogues thereof of formula (1) where R1=a hydrogen atom. R2=a hydroxy group, R1 and R2 together form =0, R3, R4, and R5 independently=a hydrogen atom, a hydroxy group or a (C1-C2) alkoxy group, R6-11 , (C1-C12) alkyl, (CH2)nNR7R8, or -(CH2)nN'R7R8R9 where n-1 to 12 Z=two hydrogen atoms, or an oxygen atom and X=an oxygen, sulphur or nitrogen atom, or a -SO, -SO2, or -NR6 group where R6 is as defined above or is an amine protecting group.