发明名称 |
6-Aryl-7-halo-imidazo[1,2-a]pyrimidines as anticancer agents |
摘要 |
This invention relates to certain 6-aryl-7-halo-imidazo[1,2-a]pyrimidines or pharmaceutically acceptable salts thereof, and compositions containing said compounds or pharmaceutically acceptable salts thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals by promotion of microtubule polymerization. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or pharmaceutically acceptable salts thereof.
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申请公布号 |
US2005065167(A1) |
申请公布日期 |
2005.03.24 |
申请号 |
US20040950542 |
申请日期 |
2004.09.24 |
申请人 |
WYETH HOLDINGS CORPORATION |
发明人 |
ZHANG NAN;AYRAL-KALOUSTIAN SEMIRAMIS |
分类号 |
A61K31/519;A61P35/00;C07D487/02;C07D487/04;(IPC1-7):A61K31/519 |
主分类号 |
A61K31/519 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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