METHODS FOR IDENTIFYING MODULATORS OF PROTEIN KINASE C-EPSILON (PKCɛ) AND METHOD OF TREATMENT OF ABERRANT GLUCOSE METABOLISM ASSOCIATED THEREWITH

摘要

The present invention provides novel cell-based and animal-based assays for determining antagonists of PKCɛand uses of the isolated antagonist compounds for modulating insulin clearance and secretion. The invention also provides novel animals and cells such as animals and cells suitable for use in the assays.