发明名称 |
Neutral amino acid transporter and gene thereof |
摘要 |
A novel amino acid transporter molecule mediating transportation of amino acids, which are nutrients essentially required in the survival and proliferation of various normal cells constituting a living body and various pathology-associated abnormal cells such as tumor cells, into cells and being expressed specifically in tumor cells compared with normal cells; and drugs for treating various pathogenic conditions such as tumor (cancer) which are obtained by identifying and isolating the above amino acid transporter molecule and identifying a substance capable of inhibiting the biological activity and/or expression of this molecule. Intensive studies were made to identify a tumor cell membrane surface molecule associating or interacting with a cell membrane surface 4F2hc molecule seemingly playing an important role in the activation of an unknown amino acid transporter. As a result, a gene encoding the novel amino acid transporter molecule, which mediates the incorporation of various neutral amino acids, various drugs or physiological substances into cells, has been found out and a substance capable of inhibiting the incorporation of amino acids via this molecule and thus inhibiting the proliferation of tumor cells has been also found out.
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申请公布号 |
US2005064475(A1) |
申请公布日期 |
2005.03.24 |
申请号 |
US20040912983 |
申请日期 |
2004.08.05 |
申请人 |
JAPAN SCIENCE AND TECHNOLOGY CORPORATION |
发明人 |
ENDOU HITOSHI;KANAI YOSHIKATSU |
分类号 |
C12N15/09;A01K67/027;A61K31/711;A61K38/00;A61K39/395;A61K48/00;A61P35/00;C07K14/705;C07K16/28;C12N5/10;C12N15/12;C12P21/08;C12Q1/02;C12Q1/68;C12R1/91;G01N33/53;G01N33/566;G01N33/577;(IPC1-7):C12Q1/68;G01N33/567;C07H21/04 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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