USE OF PPAR-GAMMA AGONISTS AS ANTI-INFECTIVE AGENTS

摘要

The invention relates to a method of producing a therapeutic composition that stimulates the innate immune response by induction and/or amplification of the expression of macrophage mannose receptors. Advantageously, the invention is applicable for preventive or curative treatments for infectious diseases of bacterial, fungal, protozoan, etc. origin and is of particular interest in the treatment of immunodepressed patients. According to the invention, in order to induce and/or amplify the expression of the macrophage mannose receptor, the aforementioned macrophages are brought into contact with an effective quantity of at least one agonist ligand of the PPAR< nuclear receptor.