<p>A stable, sterile aqueous solution of a compound of formula (I): in which A is a C alkylene group with a chain length between NH and N(O)R'R" of at least 2 carbon atoms and R' and R" are each separately selected from C1-4 alkyl groups and C2-4 hydroxyalkyl and C2-4 dihydroxyalkyl groups, or R' and R" together are a C2-6 alkylene group, is formulated in a unit dosage form in a sealed container, said solution having a concentration of the compound of formula (I) up to 150 mg/ml and a pH in the range of 5 to 9. The solution may be prepared without a freeze drying step.</p>
申请公布号
WO2005025537(A1)
申请公布日期
2005.03.24
申请号
WO2004GB03954
申请日期
2004.09.16
申请人
FORD, STEVEN, JOHN;BTG INTERNATIONAL LIMITED;HALBERT, GAVIN, WILLIAM;ELLIOTT, MOIRA, ALEXANDRA
发明人
HALBERT, GAVIN, WILLIAM;FORD, STEVEN, JOHN;ELLIOTT, MOIRA, ALEXANDRA