AMIDE COMPOUNDS FOR THE TREATMENT OF HYPERLIPIDEMIA

摘要

A compound of the formula (I) Wherein R<1> is hydrogen, lower alkyl, lower alkenyl, halo(lower)alkyl, cyclo(lower)alkyl, lower alkoxy, lower alkylthio, acyl, optionally substituted aryl or NR<3>R<4>; R<2> is hydrogen; or aryl or heteroaryl, each of which may be substituted; X is direct bond or bivalent residue derived from piperazine; Y is -(A<1>)n-(A<2>)m-, wherein n and m are independently 0 or 1) ; (II) is bivalent residue derived from arene or heteroarene; and (III) is bivalent residue derived from arene or heteroarene, or a salt thereof. The compound of the present invention and a salt thereof inhibit apolipoprotein B (Apo B) secretion and are useful as a medicament for prophylactic and treatment of diseases or conditions resulting from elevated circulating levels of Apo B.