TRANSITION STATE STRUCTURE AND INHIBITORS OF THYMIDINE PHOSPHORYLASES

摘要

The transition state structure of thymidine phosphorylase is provided as a blueprint for design of transition state inhibitors. Several thymidine phosphorylase inhibitors that resemble the charge and geometry of the thymidine phosphorylase transition state are provided. Also provided are methods of inhibiting a thymidine phosphorylase, methods of treating cancer, and methods of inhibiting angiogenesis which utilize the thymidine phosphorylase transition state inhibitors.