Immunotherapeutic combinations for the treatment of tumours that overexpress gangliosides

摘要

Described are immunotherapeutic combinations that are used to impede the growth of tumour cells and/or to eliminate those cells. The method can be used to observe a therapeutic antitumour effect by combining idiotypic vaccines having an antiganglioside antibody (Ab1) as the active principle thereof with idiotypic vaccines, the active principle of which is an anti-idiotypic antibody obtained against an antiganglioside antibody (Ab2), or with vaccines, the active principle of which is one or more gangliosides. Also described are combinations of vaccines which produce a synergism of the antitumour effect, which is induced separately by each of the vaccines. The combinations can be applied to patients in different clinical states with tumours that overexpress gangliosides.