In various embodiments, the present invention is drawn to antibodies or antigen-binding fragments thereof that bind to a vertebrate high mobility group box (HMGB) polypeptide, methods of detecting and/or identifying an agent that binds to an HMGB polypeptide, methods of treating a condition in a subject characterized by activation of an inflammatory cytokine cascade and methods of detecting an HMGB polypeptide in a sample.
申请公布号
WO2005026209(A2)
申请公布日期
2005.03.24
申请号
WO2004US29527
申请日期
2004.09.10
申请人
CRITICAL THERAPEUTICS, INC.;NEWMAN, WALTER;QIN, SHIXIN;O'KEEFE, THERESA;OBAR, ROBERT
发明人
NEWMAN, WALTER;QIN, SHIXIN;O'KEEFE, THERESA;OBAR, ROBERT