发明名称 |
METHODS AND COMPOSITIONS FOR THE EXTENDED DURATION PREVENTION AND TREATMENT OF PAIN, INFLAMMATION AND INFLAMMATION-RELATED DISORDERS |
摘要 |
A method is disclosed for providing extended duration treatment or prevention of pain, inflammation and inflammation-related disorders in a subject in need of such extended duration treatment or prevention by administering to the subject a Cox-2 selective inhibitor having certain added substituent groups. Also disclosed is a method for extending the duration of the plasma half-life of diaryl-substituted Cox-2 selective inhibitors by substituting halogen, haloalkyl, haloalkoxy, alkyl, nitrile, cyano or alkoxy groups at certain positions on the diaryl-substituted rings of the inhibitor molecule. A novel composition comprising such extended duration Cox-2 selective inhibitors is also disclosed. |
申请公布号 |
WO2005025510(A2) |
申请公布日期 |
2005.03.24 |
申请号 |
WO2004US29703 |
申请日期 |
2004.09.10 |
申请人 |
PHARMACIA CORPORATION;HUMMEL, BERNARD, D.;CARTER, JEFFERY, S. |
发明人 |
HUMMEL, BERNARD, D.;CARTER, JEFFERY, S. |
分类号 |
A61K;A61K31/365;A61K31/4152;A61K31/44;A61K31/4439 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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