| 摘要 |
Compounds of the formula (I) or a pharmaceutically acceptable salt or isomer thereof, pharmaceutical compositions and combinations with antiviral or anti-inflammatory agents that are suitable for the treatment of HIV, solid organ transplant rejection, graft v. host disease, inflammatory diseases, atopic dermatitis, asthma, allergies or multiple sclerosis are disclosed, wherein: Q, X and Z are CH or N; R, R4-R7 and R13 are H or alkyl; R1 is H, alkyl, fluoroalkyl, R9-arylalkyl, R9-heteroarylalkyl, alkyl-SO2-, cycloalkyl-SO2-, fluoroalkyl-SO2-, R9-aryl-SO2-, R9-heteroaryl-SO2-, N(R22)(R23)-SO2-, alkyl-C(O)-, cycloalkyl-C(O)-, fluoroalkyl-C(O)-, R9-aryl-C(O)-, NH-alkyl-C(O)- or R9-aryl-NH-C(O)-; R2 is H and R3 is H, alkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, R9-aryl, R9-arylalkyl, R9-heteroaryl, or R9- heteroarylalkyl, and when X and Z are each CH, R3 is alkoxy, R9-aryloxy, R9-heteroaryloxy, alkyl-C(O)O-, alkylamino- C(O)O-, alkyl-C(O)NR13-, alkyl-OC(O)NR13- or alkylamino-C(O)NR13-; or R2 and R3 together are =O, =NOR10, =N- NR11R12 or =CH-alkyl; R8 is substituted phenyl, substituted heteroaryl, naphthyl, fluorenyl, diphenymethyl, alpha- substituted benzyl or alpha-substituted heteroarylmethyl; R9, R22 and R23 are as defined in the specification.
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