| 发明名称 |
POLYETHYLENEGLYCOL-MODIFIED LIPID COMPOUNDS AND USES THEREOF |
| 摘要 |
Polyethyleneglycol (PEG) dialkyloxypropyl (DAA) lipid conjugates are disclos ed which have increased stability over commonly used PEG-lipids conjuguates. Liposomal compositions, stabilized plasmid-lipid particles (SPLP) and stabilized nucleic acid-lipid particles (SNALP) comprising said PEG-DAA conjuguates, for delivery of a bioactive agent to a cell or patient are described. |
| 申请公布号 |
CA2551022(A1) |
申请公布日期 |
2005.03.24 |
| 申请号 |
CA20042551022 |
申请日期 |
2004.09.15 |
| 申请人 |
PROTIVA BIOTHERAPEUTICS, INC. |
发明人 |
AMBEGIA, ELLEN GRACE;MACLACHLAN, IAN;HEYES, JAMES |
| 分类号 |
C12N15/88;A61K9/127;A61K31/7088;A61K47/44;A61K47/48;A61K48/00;C07C233/18;C07C235/06;C07C235/08;C07C271/16;C07C275/06;C07C321/14;C07H21/00 |
主分类号 |
C12N15/88 |
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