Use of sucralose as a sweetening agent combined with pH modulation of chemical formulations generates enhanced taste-masking effects

摘要

Described is a pharmaceutically acceptable taste masking liquid excipient base for administration of a relatively large amount of unpleasant tasting medicines. More particularly, the enhanced sweetness and taste masking effect are produced by the addition of sucralose to the excipient base with maintenance of a pH from about 2 to about 5. Further described are medicinal compositions comprising such a liquid excipient base and unpleasant tasting medicines. Still further described is a method for taste masking unpleasant tasting medicines through their incorporation into the exemplified liquid excipient bases.