Polycycoalkylpurines as adenosine receptor antagonists

摘要

A polycycloalkylpurine derivative of formula (I) is disclosed, wherein: R1 and R2 are independently hydrogen, or optionally substituted alkyl, alkenyl, alkynyl or aryl; R3 is an optionally substituted tricyclic group of formula (II); X1 and X2 are independently O or S; Z is a single bond, -O-, -(CH2)1-3-, -O(CH2)1-2-, -CH2OCH2-, -(CH2)1-2O-, -CH=CHCH2-, -CH=CH- or -CH2CH=CH- and R6 is hydrogen, alkyl, acyl, alkylsulphonyl, aralkyl, substituted aralkyl or substituted alkyl or heterocyclyl. These compounds are useful in treating a condition characterized by an elevated adenosine concentration and/or increased sensitivity to adenosine such as cardiac and circulatory disorders, degenerative disorders of the central nervous system, respiratory disorders, diseases for which diuretic treatment is indicated, Parkinson's disease, depression, traumatic brain damage, post-stroke neurological deficit, respiratory depression, neonatal brain trauma, dyslexia, hyperactivity, cystic fibrosis, neonatal apnea, renal failure, diabetes, asthma, or edematous conditions. (62) Divided Out of 519426