Synthetic vaccine agents

摘要

An immunogen comprises at least one antigenic determinant constituted by an amino acid sequence that includes at least one B-cell epitope and/or at least one CTL epitope, and at least one second antigenic determinant constituted by an amino acid sequence that includes a T helper cell epitope (TH epitope). Each of the antigenic determinants are independently coupled through the nitrogen atoms at their respective NB-termini to a pharmaceutically acceptable activated polyhydroxypolymer carrier via a bond that is cleavable. The immunogen can be used in the manufacture of a medicament for immunizing an animal.