发明名称 |
MONOCLONAL ANTIBODIES AGAINST HMGB1 |
摘要 |
<p>In various embodiments, the present invention is drawn to antibodies or antigen-binding fragments thereof that bind to a vertebrate high mobility group box (HMGB) polypeptide, methods of detecting and/or identifying an agent that binds to an HMGB polypeptide, methods of treating a condition in a subject characterized by activation of an inflammatory cytokine cascade and methods of detecting an HMGB polypeptide in a sample.</p> |
申请公布号 |
CA2882022(A1) |
申请公布日期 |
2005.03.24 |
申请号 |
CA20042882022 |
申请日期 |
2004.09.10 |
申请人 |
CRITICAL THERAPEUTICS, INC. |
发明人 |
NEWMAN, WALTER;QIN, SHIXIN;O'KEEFE, THERESA;OBAR, ROBERT |
分类号 |
C07K16/18;A61K39/395;C07K14/47;C07K16/46;C12N5/10;C12N5/16;C12N5/20;C12P21/08;G01N33/577 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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