发明名称 |
Mutants of streptococcal toxin A and methods of use |
摘要 |
This invention is directed to mutant SPE-A toxins or fragments thereof, vaccine and pharmaceutical compositions, and methods of using the vaccine and pharmaceutical compositions. The preferred SPE-A toxin has at least one amino acid change and is substantially non-lethal compared with the wild type SPE-A toxin. The mutant SPE-A toxins can form vaccine compositions useful to protect animals against the biological activities of wild type SPE-A toxin.
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申请公布号 |
US6870042(B1) |
申请公布日期 |
2005.03.22 |
申请号 |
US20030625221 |
申请日期 |
2003.07.22 |
申请人 |
REGENTS OF THE UNIVERSITY OF MINNESOTA |
发明人 |
SCHLIEVERT PATRICK M.;ROGGIANI MANUELA;STOEHR JENNIFER;OHLENDORF DOUGLAS |
分类号 |
A61K38/00;A61K39/00;C07K14/315;(IPC1-7):C07H21/04 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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