发明名称 |
Bifunctional boronic compound complexing reagents and complexes |
摘要 |
A reagent having the general formula of General Formula I:wherein group R is an electrophilic or a nucleophilic moiety suitable for reaction of the reagent with a biologically active species; group R2 is one of H and OH moieties; group R3 is one of an alkyl and a methylene bearing an electronegative substituent; group Z is one of (CH2)n and CH2O(CH2CH2O)n2, and n is an integer of from 1 to 5, and n2 is an integer of from 1 to 4; and each of group Z2 and Z3 are (CH2)CONH(CH2)3CONH(CH2)2. Also, a reagent having the general formula of General Formula II:group R2 is one of H and OH moieties; group Z is one of (CH2)n and CH2O(CH2CH2O)n2, and n is an integer of from 1 to 5, and n2 is an integer of from 1 to 4; each of group Z2 and group Z3 include one of (CH2)CONH(CH2)3CONH(CH2)2; and (CH2)CONH(CH2); and group R is an electrophilic or a nucleophilic moiety suitable for reaction of the reagent with the biologically active species.
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申请公布号 |
US6870065(B2) |
申请公布日期 |
2005.03.22 |
申请号 |
US20020184836 |
申请日期 |
2002.06.28 |
申请人 |
CAMBREX BIO SCIENCE ROCKLAND, INC. |
发明人 |
AHLEM CLARENCE N.;KAISER ROBERT J.;LUND KEVIN P.;STOLOWITZ MARK L. |
分类号 |
C07C229/38;C07C233/49;C07C237/22;C07C255/13;C07C259/10;C07C271/22;C07C281/02;G01N33/543;(IPC1-7):C07C229/38;C07C255/00 |
主分类号 |
C07C229/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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